Inflammation in neurological disorders: a help or a hindrance?
Identifieur interne : 001A30 ( Main/Exploration ); précédent : 001A29; suivant : 001A31Inflammation in neurological disorders: a help or a hindrance?
Auteurs : V. Wee Yong [Canada]Source :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1089-4098 ] ; 2010.
English descriptors
- KwdEn :
- Brain (metabolism), Brain (pathology), Humans, Inflammation (complications), Inflammation (metabolism), Inflammation (pathology), Inflammation Mediators (metabolism), Nerve Regeneration (physiology), Nervous System Diseases (complications), Nervous System Diseases (metabolism), Nervous System Diseases (pathology).
- MESH :
- chemical , metabolism : Inflammation Mediators.
- complications : Inflammation, Nervous System Diseases.
- metabolism : Brain, Inflammation, Nervous System Diseases.
- pathology : Brain, Inflammation, Nervous System Diseases.
- physiology : Nerve Regeneration.
- Humans.
Abstract
Inflammation of the central nervous system (CNS) (neuroinflammation) is now recognized to be a feature of all neurological disorders. In multiple sclerosis, there is prominent infiltration of various leukocyte subsets into the CNS. Even when there is no significant inflammatory infiltrates, such as in Parkinson or Alzheimer disease, there is intense activation of microglia with resultant elevation of many inflammatory mediators within the CNS. An extensive dataset describes neuroinflammation to have detrimental consequences, but results emerging largely over the past decade have indicated that aspects of the inflammatory response are beneficial for CNS outcomes. Benefits of neuroinflammation now include neuroprotection, the mobilization of neural precursors for repair, remyelination, and even axonal regeneration. The findings that neuroinflammation can be beneficial should not be surprising as a properly directed inflammatory response in other tissues is a natural healing process after an insult. In this article, we review the data that highlight the dual aspects of neuroinflammation in being a hindrance on the one hand but also a significant help for recovery of the CNS on the other. We consider how the inflammatory response may be beneficial or injurious, and we describe strategies to harness the beneficial aspects of neuroinflammation.
DOI: 10.1177/1073858410371379
PubMed: 20817918
Affiliations:
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Le document en format XML
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Wee Yong</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Alberta, Canada. vyong@ucalgary.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="RBID">pubmed:20817918</idno><idno type="pmid">20817918</idno><idno type="doi">10.1177/1073858410371379</idno><idno type="wicri:Area/PubMed/Corpus">000D22</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D22</idno><idno type="wicri:Area/PubMed/Curation">000D22</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D22</idno><idno type="wicri:Area/PubMed/Checkpoint">000D22</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D22</idno><idno type="wicri:Area/Ncbi/Merge">000D33</idno><idno type="wicri:Area/Ncbi/Curation">000D33</idno><idno type="wicri:Area/Ncbi/Checkpoint">000D33</idno><idno type="wicri:Area/Main/Merge">001B38</idno><idno type="wicri:Area/Main/Curation">001A30</idno><idno type="wicri:Area/Main/Exploration">001A30</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Inflammation in neurological disorders: a help or a hindrance?</title><author><name sortKey="Wee Yong, V" sort="Wee Yong, V" uniqKey="Wee Yong V" first="V" last="Wee Yong">V. Wee Yong</name><affiliation wicri:level="4"><nlm:affiliation>University of Calgary, Calgary, Alberta, Canada. vyong@ucalgary.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>University of Calgary, Calgary, Alberta</wicri:regionArea><orgName type="university">Université de Calgary</orgName><placeName><settlement type="city">Calgary</settlement><region type="state">Alberta</region></placeName></affiliation></author></analytic><series><title level="j">The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry</title><idno type="eISSN">1089-4098</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Brain (metabolism)</term><term>Brain (pathology)</term><term>Humans</term><term>Inflammation (complications)</term><term>Inflammation (metabolism)</term><term>Inflammation (pathology)</term><term>Inflammation Mediators (metabolism)</term><term>Nerve Regeneration (physiology)</term><term>Nervous System Diseases (complications)</term><term>Nervous System Diseases (metabolism)</term><term>Nervous System Diseases (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Inflammation Mediators</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Inflammation</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Brain</term><term>Inflammation</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Brain</term><term>Inflammation</term><term>Nervous System Diseases</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Nerve Regeneration</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Inflammation of the central nervous system (CNS) (neuroinflammation) is now recognized to be a feature of all neurological disorders. In multiple sclerosis, there is prominent infiltration of various leukocyte subsets into the CNS. Even when there is no significant inflammatory infiltrates, such as in Parkinson or Alzheimer disease, there is intense activation of microglia with resultant elevation of many inflammatory mediators within the CNS. An extensive dataset describes neuroinflammation to have detrimental consequences, but results emerging largely over the past decade have indicated that aspects of the inflammatory response are beneficial for CNS outcomes. Benefits of neuroinflammation now include neuroprotection, the mobilization of neural precursors for repair, remyelination, and even axonal regeneration. The findings that neuroinflammation can be beneficial should not be surprising as a properly directed inflammatory response in other tissues is a natural healing process after an insult. In this article, we review the data that highlight the dual aspects of neuroinflammation in being a hindrance on the one hand but also a significant help for recovery of the CNS on the other. We consider how the inflammatory response may be beneficial or injurious, and we describe strategies to harness the beneficial aspects of neuroinflammation.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Wee Yong, V" sort="Wee Yong, V" uniqKey="Wee Yong V" first="V" last="Wee Yong">V. Wee Yong</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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